Safety of Repeated Injectables: What Do the Studies Say?

injections treatment plans

If you’re considering scheduling a Quality Facial Injectables Plan that involves anti-ageing and wrinkle-reduction injections, you’ll want to know that repeated Injectables are truly safe.

Here are two different medical studies on the topic of Safety of Injectables – here’s what the non-biased researchers found.

Injectable Facial Fillers or Dermal Volumisers

Researchers in India were concerned about whether or not bone fillers were causing any long-term damage.

The fillers made of hydroxyapatite nanoparticles are smaller than 50 nanometres ( a human hair is 80,000 nanometres). Researchers questioned whether they could conceivably accumulate in organs.

  • When tested in animal studies for 28 days, blood, liver, and organs showed no accumulation of the nanoparticles.
  • The antioxidant defense mechanisms were not changed, indicating the use of the fillers was safe.

Facial Injectables, Facial Fillers and Granulomas

Injectables may cause the appearance of granulomas in some people (a granuloma is a collection of immune function cells which are known as histiocytes).  Usually granulomas occur because of an infection in the skin. Even this rare potential side effects may be overcome by medical treatment, and at Coco Ruby Skin & Anti-Ageing, our Surgeons and Doctors and Senior Nurse Injectors are all trained in how to best manage any potential rare complications.

A great injector can screen for potential problems relating to injectables and will also have quality treatment protocols in place – along with expert knowledge – should any rare side effects occur.

A great injector will also help you to avoid “Filler Over-Use Syndrome.”

best injecting GP nurse practitioner melbourne for fillers

Read our great blogs on Facial Injectables (Anti-Wrinkle Injections and Dermal Fillers) by following the links below:

Five Fibs About Fillers (By Aesthetic Physician Dr Prav)

Avoiding Filler Over-Use Syndrome (By Senior Injecting Nurse Kay)

Liquid Facelift (By Senior Injecting Sandra)

Patient’s First Injectables Experience Story Part I
Patient’s First Injectables Experience Story Part II (By Maven)


Do you have any other questions about injectables? Give our Patient Care Adviser or expert Injectors a call on (03) 8849 1400 and get your questions answered.

Our Melbourne & Berwick Injectors are highly regarded for:

  • Over 20 years of experience
  • Advanced Aesthetic Injecting Training
  • In depth understandings of Facial Anatomy for Best Results
  • Quality Treatment Plans
  • Strategic Injectables placement
  • Minimising any potential discomfort during treatment
  • Aligned with Melbourne’s top Plastic Surgeons

Our Senior Injecting Nurses (Kay and Sandra) have from 10 to 20 years of cosmetic injectables experience. Our team also features a leading Aesthetic Physician (Dr Prav).

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All of our Injectors are renowned for quality work – and for not being over-zealous.

This ensures you get natural-looking feature enhancements & wrinkle reductions using injectables that can help rejuvenate your entire facial appearance – plus long lasting results that won’t look ‘over-done.’

There’s nothing worse in the cosmetic injectables arena than seeing someone who’s been the patient of an over-zealous injector or an inexperienced injector (and there are DANGER ZONES for injectables you’ll want to know about also).

At Coco Ruby, we have NO NOVICE  injectors at our Clinics. Our highly experienced Injecting Team is also supported by Melbourne’s leading Plastic Surgeons at Medici Clinic in Berwick, Cosmetic Surgery for Women and Aesthetic Surgery for Men.

Give us a call on (03) 8849 1400 or send an enquiry today and get started on a Quality Injectables Treatment Plan with a senior Clinician.


Injecting Safety Study References relating to Repeated Dermal Fillers & Anti-Wrinkle Injections

Parayanthala, V.M., Santhakumar, S. and Arumaugam, S. Determination of oxidative stress related toxicity on repeated dermal exposure of hydroxyapatite nanoparticles in rats. Int J Biomater 2014; 2014: 476942.

Lemperle, G., Gauthier-Hazan, N. Foreign body granulomas after all injectable dermal fillers:  2 treatment options. Plast Reconstr Surg 2009 Jun; 123(6): 1864-73.